The association of depression with motoric cognitive risk syndrome: Results from the Canadian longitudinal study on aging


Motoric Cognitive Risk syndrome (MCR) as well as depression and depressive symptoms (i.e. anxiety, depressive symptomatology and/or clinical depression — ADSCD) are associated with cognitive complaint and slow gait speed. Overlap with other syndromes (such as depression and/or depressive symptoms) may influence the predictive value of MCR.


  • To examine whether there was an association between ADSCD and MCR in the participants of the Canadian Longitudinal Study on Aging (CLSA)
  • To determine whether the nature of depressive symptoms and age may influence this association


The design is a cross-sectional study, which used the baseline assessment of CLSA.

A total of 29,569 participants from the CLSA were included after excluding those 1) lacking walking speed data and/or 2) diagnosed with dementia or AD. Participants were categorized by age groups and MCR diagnosis. Intra-group comparisons were completed using the unpaired t-test or Chi square test. Multiple logistic regressions were also performed to examine the association between MCR and depressive symptomatology, while adjusting for multiple variables.


MCR may be a clinical manifestation of depression or depressive symptomology in younger individuals, whereas it may be related to both depression and the predementia phase in older adults.


Jewish General Hospital, Montreal

Faculty of Medicine, McGill University

McMaster University, Hamilton (ON)